Lipoproteins are the particles that transport cholesterol and triglycerides in the blood stream.
Lipoproteins are composed of proteins (apolipoproteins), phospholipids, triglycerides and cholesterol.
The lipoproteins vary in the major lipoprotein present and the relative contents of the different lipid components.
Lp(a) is a lipoprotein rich in cholesterol. It differs from LDL as it contains an additional protein, apolipoprotein (a). Similar to LDL, a Lp(a) particle also contains one molecule of apolipoprotein B.
It as assumed that Lp(a) is produced by liver cells. However, the pathways for the clearance of this substance are not clearly understood.
Plasma levels of Lp(a) rise shortly after birth and the levels appear to become consistent within a few months.
In adults, plasma levels of Lp(a) vary widely, ranging from 0.2 – 250 mg/dL. The levels are similar in men and women.
Studies indicate that about one in five individuals have plasma levels above 50 mg/dL (80th percentile), and about one in four have plasma levels above 32 mg/dL (75th percentile). Lp(a) levels less than 30 mg/dL are considered normal.
Here’s how Lp(a) lelevls are looked at in terms of risk:
Desirable: < 14 mg/dL (< 35 nmol/l)
Borderline risk: 14 – 30 mg/dL (35 – 75 nmol/l)
High risk: 31 – 50 mg/dL (75 – 125 nmol/l)
Very high risk: > 50 mg/dL (> 125 nmol/l)
About 20% or one in five people have high levels of Lp(a) greater than 50mg/dL from birth based on genetic factors they inherited from their parents, and most don’t know they have it. As high levels of Lp(a) travel through the bloodstream, it collects in the arteries, leading to gradual narrowing of the artery that can limit blood supply to the heart, brain, and kidneys as well as the legs. It can increase the risk of blood clots, heart attack or stroke.
Family History of Premature Heart Disease/Heart Attack; Men <40 years of age, Women <50 years of age. No
Family History of High Blood Pressure, Diabetes, Stroke or Kidney Disease. No
Lipoprotein(a) [Lp(a)] >30 mg/dL or 75 nmols/L Yes – 192 nmol/l (very high risk)
Age ≥ 50 males; ≥ 60 female Yes
High Blood Pressure >130/90 mm Hg No
Total Cholesterol >200 mg/dL Yes – 269 (high risk)
LDL-C (Low Density Lipoprotein Cholesterol) > 100 mg/dL Yes – 165 (high risk)
Cholesterol/HDL-C ratio > 3.5 No – 3.3 (optimum)
HDL-C (High Density Lipoprotein Cholesterol) <40 (male)/50 (female) mg/dL No-81 (optimum)
TG (Triglycerides) > 150 mg/dL No – 111 (optimum)
NON-HDL-C >130 mg/dL Yes – 188 (moderate risk)
LDL-P >1000 nmols/L Yes – 1343 (moderate risk)
Apolipoprotein B >80mg/dL Yes – 111 (moderate risk)
Fasting Blood Glucose >100 mg/dL No (guessing)
Smoking (including secondhand) No
BMI (Body Mass Index) >28 Kg/m2 No
Waist Circumference >35″ Women; 40″ Men No
Less than 30 Minutes Physical Activity Daily No
This guy. The one who just backpacked 10 miles into the Grand Canyon with his daughter to make some memories.
The guy who carried a 50 pound pack on his back and didn’t have a heart attack. But he seems to be at risk.
Better to know than not I guess. Stay tuned.
I am going to get more information to understand my risk better. Specifically,
Mark aka The Old Spartan and Over-50 Fitness Savior is a 63 year old coffee guzzling father of five wandering the outdoors around Albuquerque, New Mexico. Mark helps Active Boomers get lean, healthy and strong so they can be great role models and they live rewarding lives using his signature Spartan Method system.
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